In the new round of strategic action for mineral exploration breakthroughs, the Xi'an Mineral Resources Survey Center of the China Geological Survey implemented the first large-diameter borehole (BUZK15) with a depth exceeding 15 kilometers in the Jingchuan area of the Ordos Basin. To meet the technical requirements for final hole diameter, core diameter, and other key indicators specified by the geological tasks, the project team optimized the borehole structure and innovatively introduced a non-standard S110 wireline coring technique. This led to the development of a deep-hole wireline coring technical solution suitable for aeolian sandstone-type uranium deposits. Field applications demonstrate that this technique performs remarkably well in large-diameter, deep-hole drilling for sandstone-type uranium deposits, which exhibits strong technical feasibility and geological adaptability. Compared with conventional single-tube drill-pipe retrieval coring methods, the adoption of this technique increases core recovery by 15%, controls the average deviation of borehole inclination to within 0.21° per hundred meters. It achieves a pure drilling efficiency of 63.24%, and attains an average hourly drilling rate of 2.72 m/h. While significantly enhancing operational efficiency and core quality, it effectively reduces labor intensity, indicative of considerable potential for broader application. The exploration and practice of this non-standard S110 wireline coring technique provide an important reference for deep mineral exploration projects under similar geological conditions.